Titlebook: Gene Therapy; Principles and Appli Thomas Blankenstein Book 1999 Birkh?user Verlag 1999 DNA.HIV.bacteria.biotechnology.cancer.gene expressi

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Gene Therapy for Severe Combined Immunodeficienciesoral responses [1, 2]. Affected children typically fail to thrive and become ill with recurrent infections caused by bacteria, viruses, and opportunistic pathogens. The molecular defects have now been identified for the majority of SCID phenotypes and are summarized in Table 1-1 [3–27]. The defects

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Gene Therapy for Cystic Fibrosise which these studies have created in some quarters should be qualified and countered. Remarkable progress has been made and independent strategies have been tested in the very few years since the . gene was cloned. The inadequacies of the very early generation of adenoviruses were easily predicted,

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Gene Marking in Bone Marrow and Peripheral Blood Stem Cell Transplantationhe field, clinical studies using gene-marked bone marrow will be reviewed and discussed in the context of these controversies. Autologous bone marrow transplantation and peripheral blood cell transplantation (AuBMT and AuPBPC, respectively) are becoming an increasingly common procedure for the treat

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receptors

1 Gene Transfer to Hematopoietic Cellsicularly true for hematopoietic disorders because the efficiency of gene transfer is limited and stable expression of transgenes in bone marrow has been found difficult to accomplish (Miller, 1990). In preclinical primate studies as well as in clinical trials, the percentage of hematopoietic cells e

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accomplishment

Liposomes in Gene Therapyation of their role deserves a detailed introduction. Therefore this article describes their preparation and role as a vehicle to deliver DNA molecules and the possible delivery mechanism of encapsulated materials.

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