Titlebook: Gastrointestinal Cancers: An Interdisciplinary Approach; Nima Rezaei Book 2023 The Editor(s) (if applicable) and The Author(s), under excl

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Niels Engberding,Nanette K. Wenger are increasingly relevant owing to the potential for long-term survival following treatment. Striking a balance between treating early-onset colorectal cancer while preserving bowel, bladder, sexual function, and fertility is challenging yet imperative.

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The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy,tributes to the aggressive disease phenotype and treatment resistance. In this chapter, the different components of the TME in PDAC will be described and discussed to further elucidate some of the major challenges of the TME in relation to immunotherapy.

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Atlas of Astronomical Discoveriesas a new therapeutic target and finally as a biomarker of response to conventional therapy. In the following paragraphs, we will elucidate the role of intestinal microbiota and immune system in CRC carcinogenesis as well as their interplay. Moreover, we will address the potential role of gut microbiota in CRC screening, diagnosis, and therapy.