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31#
發(fā)表于 2025-3-26 21:23:55 | 只看該作者
G Proteins in the Etiology and Treatment of Mental Disorders,heart failure, endocrine tumors, McCune-Albright syndrome, diabetes, alcoholism, schizophrenia, major valve prolapse, chronic cocaine or opiate ingestion, aging, hypo- or hyperthyroidism, and adrenalectomy or corticosteroid medication (.; .; .; .; .; .; .; .; .).
32#
發(fā)表于 2025-3-27 03:02:06 | 只看該作者
G Proteins and Mood Disorders,gic, serotonergic, and cholinergic) possibly owing to changes in receptor sensitivity (Post and Ballenger, 1984). These data have resulted in a recent and relatively extensive field of research investigating mechanisms that regulate receptor responsivity, which has focused to a large extent on the G protein-coupled signal transduction pathways.
33#
發(fā)表于 2025-3-27 07:59:02 | 只看該作者
,In Vitro Autoradiographic Localization of Receptor-Stimulated [35S]GTPγS Binding in Brain,signaling component, which translates the binding of the neurotransmitter (or its agonists) into a physiological response. Radioligand binding assays represented a breakthrough in understanding the properties of these receptors in brain at the level of the ligand binding site, and the development of
34#
發(fā)表于 2025-3-27 13:21:45 | 只看該作者
35#
發(fā)表于 2025-3-27 15:57:35 | 只看該作者
G Proteins in the Etiology and Treatment of Mental Disorders,he expression and/or function of various G proteins has been implicated in a multitude of pathophysiological states: pseudohypoparathyroidism (PsHP), heart failure, endocrine tumors, McCune-Albright syndrome, diabetes, alcoholism, schizophrenia, major valve prolapse, chronic cocaine or opiate ingest
36#
發(fā)表于 2025-3-27 18:23:14 | 只看該作者
,G Protein α- and βγ-Subunits as Possible Mediators of Dopamine-D1:D2 Receptor Ligand Binding Interahways that involve subtype-specific guanine nucleotide binding or G proteins (see .; .; .; .; .; .; .; .). On the basis of biochemical, pharmacological and physiological criteria, receptors for dopamine within the central nervous system and periphery have been classified into two types, termed Dl an
37#
發(fā)表于 2025-3-28 01:28:05 | 只看該作者
38#
發(fā)表于 2025-3-28 05:58:05 | 只看該作者
,G Proteins and Animal Models of Parkinson’s Disease,lar responses to chemical transmitters. Typically, alterations in neurotransmitter status can either result in reduced receptor activity, also known as receptor desensitization, or increased receptor activity, referred to as receptor supersensitivity. Receptor desensitization has perhaps been best c
39#
發(fā)表于 2025-3-28 07:33:49 | 只看該作者
Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling,rotein kinase C (PKC) has been regarded as one of the early steps in receptor signaling (., .; .; .). The generation of the second messengers DAG and calcium by receptor-mediated phospholipase C (PLC) activation leads to rapid activation of several isoforms of PKC (.), its translocation to the membr
40#
發(fā)表于 2025-3-28 14:11:14 | 只看該作者
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