Titlebook: Epigenome Editing; Methods and Protocol Albert Jeltsch,Marianne G. Rots Book 2024Latest edition The Editor(s) (if applicable) and The Autho

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Fine-Tuning the Epigenetic Landscape: Chemical Modulation of Epigenome Editorss toolbox. Here, we provide a comprehensive review of the current state of these cutting-edge systems and specifically discuss their advantages and limitations, offering context to better understand their capabilities.

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Reader-Effectors as Actuators of Epigenome Editing where abnormal and context-specific reader-effectors might impair the effects of epigenome editing. Lastly, we discuss how engineered reader-effectors may complement the epigenome editing toolbox to achieve robust and reliable gene regulation.

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Optimized Protocol for the Regulation of DNA Methylation and Gene Expression Using Modified dCas9-Su 22 amino acids. Moreover, we describe the co-recruitment of TET1 and VP64 for efficient gene activation. Since we showed the manipulation of DNA methylation at specific loci and gene activation, its application could lead to its future use in the clinic.

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Fluorescent Reporter Systems to Investigate Chromatin Effector Proteins in Living Cellsof regulatory dependencies of the investigated chromatin regulator on endogenous cofactors. The system allows for an easy and dynamic readout at the single-cell level and the ability to compensate for cell-to-cell variances of transcription. The modular design of the system enables the simple adjust

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