Titlebook: Exosomes, Stem Cells and MicroRNA; Aging, Cancer and Ag Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar Book 2018 Springer International Pu

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Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathyociation of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D) and type 2 DM (T2D). T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood. It is caused due to p

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Stem Cell Therapies for Neurodegenerative Diseasesr neuroregeneration remain uncertain. Embryonic stem cells (ESCs) and neural stem cells (NSCs), which can efficiently generate neural cells, could be good candidates but they pose ethical and practical issues. Not only difficult to find the good source of those cells but also they alway pose immunor

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Exosomes Function in Tumor Immune Microenvironmentnsing “signals” released from tumor cells. Together with other stromal cells, they form the soil for malignant cell progression. In the crosstalk between tumor cells and its surrounded microenvironment, exosomes exert multiple functions in shaping tumor immune responses. In tumor cells, their exosom

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EV, Microvesicles/MicroRNAs and Stem Cells in Cancerate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic sites for the attachment and growth of tumor tissue. Through an interaction with a range of host tissues, EVs are able to generate a pro-tumor environment that is essential for tumorigenesis. These s

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Human Aging and Cancer: Role of miRNA in Tumor Microenvironmenteads from vulnerability to death. Mammalian somatic cells display limited proliferative properties . that results in a process of permanent cell cycle arrest commonly known as senescence. Events leading to cellular senescence are complex but may be due to the increase in tumor suppressor genes, caus

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