Titlebook: Excitatory Amino Acids and Second Messenger Systems; Vivian I. Teichberg,Lechoslaw Turski Conference proceedings 1991 Springer-Verlag Berl

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后來(lái)

Neuromodulation of Non-NMDA Class Glutamate Receptor Channels in Hippocampal Neurons,Receptor channels activated by glutamate play a central role in brain function and have been implicated not only in memory, but also in excitotoxicity, and neurodegenerative diseases [1]. Although much work has been done to characterize the glutamate receptor channels, little is known regarding the neuro-modulation of their activities.

LIEN

Diversity and Organization of Excitatory Amino Acid Receptors in the CNS, the action of many drugs. At a first approximation, the anatomical organization of nerve terminals that release excitatory amino acids (EAAs) appears quite simple. Most synapses in the vertebrate CNS that display fast, excitatory transmission probably use an EAA as their neurotransmitter; most syna

Proclaim

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Diatribe

Evidence that Arachidonic Acid Plays a Role in Long-Term Potentiation,rgely because it is considered to be a possible biological substrate for learning and memory. LTP is a remarkable form of synaptic plasticity which describes a long lasting change in synaptic efficacy following a brief train of high-frequency stimulation. Although the molecular mechanisms underlying

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EXALT

Intracellular and Intercellular Messengers Produced by Metabotropic (Qp), AMPA, and NMDA Excitatory GTP-binding protein). The first class includes the .-methyl-D-aspartate (NMDA), .-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate (KA) receptors. Recently, several clones (at least six) encoding for functional AMPA and one clone encoding for functional KA receptors have been sequ

helper-T-cells

Glutamate Receptors, Nitric Oxide, and Cyclic GMP,nd that application of glutamate by microinjection in vivo or to brain slices in vitro, was able to provoke large increases in the levels of cyclic guanosine monophosphate (cGMP) [1, 2]. A few years later, it was demonstrated that activation of excitatory pathways in vivo would also produce this res

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