Titlebook: Excitatory Amino Acids; Peter J. Roberts,Jon Storm-Mathisen,Harry F. Bradf Book 1986 The Editors and the Contributors 1986 amino acid.huma

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Funktion, Abbildung, Farbe, Raum,rones (Curtis et al., 1960), and subsequent studies which first showed the more powerful and often more prolonged actions of many other natural and non-natural compounds possessing the same general pattern of functional groups were also conducted in this tissue (Curtis and Watkins, 1960, 1963; Bisco

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,Formelle Gesetze im r?mischen Rechte,nan, 1983). Much of this classification has been derived from experiments on isolated CNS preparations, in particular the amphibian spinal cord in vitro. This preparation was first described nearly a quarter of a century ago as a very useful model system to screen the basic pharmacological propertie

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https://doi.org/10.1007/978-3-658-33690-5mpts to exploit these techniques to label receptors for the excitatory amino acids were reported in 1974 by Roberts and by Michaelis and his coworkers. Using synaptic membrane fractions isolated from the rat brain, these authors demonstrated the presence of a population(s) of L-[14C]glutamate bindin

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https://doi.org/10.1007/978-3-662-32995-5he CNS. Autoradiography allows a quantitative description of anatomical and pharmacological properties of binding sites in specific CNS locations which can then be correlated to function. Receptors in a single dendritic field can be both biochemically characterized and rigorously studied by electrop

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Identification of Pathways for Acidic Amino Acid Transmitters and Search for New Candidates: SulphuIn this paper, the emphasis will be given on two topics: (I) The information which can be drawn from selective retrograde labeling of CNS pathways while using D-[3H]-?SP as a marker. (II) The search for new neuroac-tive substances, possibly involved in neurotransmission.

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The Editors and the Contributors 1986