Titlebook: Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle; George B. Frank,C. Paul Bianchi,Henk E. D. J. Keur Book 1992 The

推遲

Analysis of Factors Involved in the Tissue Selectivity of Calcium Antagonistseptors where H. antagonists do not interact with H. receptors and vice versa. A question that has been raised several times (Godfraind et al., 1986), is the existence of a possible tissue selectivity of calcium antagonists. In other words, does any selectivity exist in the pharmacology of calcium channels ?

Foreknowledge

Empirische Ergebnisse und Diskussion,coplasmic reticulum (SR). The investigation of this key question of the E-C coupling has resulted in two principal hypotheses about the nature of the T-SR signal transmission: (i) Ca. release from SR triggered by a change in tubular membrane polarization and (ii) Ca. release induced by specific chemical transmitter from the T-system.

拖網(wǎng)

KIN

Zhiping Shi,Yong Guan,Ximeng Li step that links channel opening to depolarization is the displacement of permanent charges (charge movement, Schneider and Chandler, 1973) found in the T-tubular membrane and localized in the DHP receptor (Ríos and Pizarro, 1991).

HACK

The Significance of Na+ in E-C Coupling in Musclecoplasmic reticulum (SR). The investigation of this key question of the E-C coupling has resulted in two principal hypotheses about the nature of the T-SR signal transmission: (i) Ca. release from SR triggered by a change in tubular membrane polarization and (ii) Ca. release induced by specific chemical transmitter from the T-system.

協(xié)迫

lanugo

ungainly

Na/Ca Exchange and First Messenger Ca in Skeletal Muscle Excitation - Contraction Couplingeen discussed at this Conference: 1) structural links spanning the t-SR gap, such as the rigid rod model (Schneider and Chandler, 1973), and 2) chemical links including trigger Ca (Bianchi, 1969 and Frank, 1980).

完成才會(huì)征服

The Functional Role of T-Tubular Calcium Channels in Skeletal Muscle Contractions For this reason in my initial studies I used high K.-induced contractures in a Na.-free solution as a model for the events occurring during e-c coupling in both types of muscle activity (Frank, 1958, 1960).

加入

Ca2+ Antagonists as Tools in the Analysis of Excitation-Contraction Coupling in Skeletal Muscle Fibrnylalkylamines (PAA.) and benzothiazepines (BTZ.). These classes appear to have different binding sites at the Ca. channel which show a reciprocal allosteric interaction among each other and with additional Ca. binding sites (Glossmann et al., 1985).