Titlebook: Evolutionary Dynamics of Malignancy; The Genetic and Envi Robert C. Jackson Book 2023 The Editor(s) (if applicable) and The Author(s), unde

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Hans-Erhard Lessing,Tony Hadlandined. Those epigenetic changes may in turn be a result of genetic or chromosomal instability. Malignant progression caused by epigenetic silencing of function of tumour suppressor genes will often require inactivation of both alleles, though in some cases loss of a single allele may result in alleli

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A Thermodynamic View of Successionr immune response. As tumour progression proceeds, genetic instability results in the developing tumour becoming increasingly immunogenic. Immune surveillance may result in early-stage tumours being eliminated without developing into clinically evident disease. Less immunogenic tumours may be held i

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Cancer as a Disease of Cell Proliferation,athways, that have mutated in malignant cells to become independent of their normal regulation. Tumour suppressor genes are recessive genes, often involved in signal transduction and apoptosis pathways, that carry loss-of-function mutations in tumour cells..Many anticancer drugs target the biochemic

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Genetic and Chromosomal Instability,inations of mutations. The process of tumour progression results from Darwinian natural selection, with cells that have a competitive advantage eventually dominating the population..An important class of anticancer drugs, the alkylating agents, acts by causing DNA damage; their antitumour selectivit