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Titlebook: Evolution and Variation of Multigene Families; Tomoko Ohta Book 1980 Springer-Verlag Berlin Heidelberg 1980 Drosophila.Molekulargenetik.an

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書目名稱Evolution and Variation of Multigene Families
編輯Tomoko Ohta
視頻videohttp://file.papertrans.cn/318/317681/317681.mp4
叢書名稱Lecture Notes in Biomathematics
圖書封面Titlebook: Evolution and Variation of Multigene Families;  Tomoko Ohta Book 1980 Springer-Verlag Berlin Heidelberg 1980 Drosophila.Molekulargenetik.an
描述During the last decade and a half, studies of evolution and variation have been revolutionized by the introduction of the methods and concepts of molecular genetics. We can now construct reliable phylogenetic trees, even when fossil records are missing, by compara- tive studies of protein or mRNA sequences. If, in addition, paleon- tological information is available, we can estimate the rate at which genes are substituted in the species in the course of evolution. Through the application of electrophoretic methods, it has become possible to study intraspecific variation in molecular terms. We now know that an immense genetic variability exists in a sexually repro- ducing species, and our human species is no exception. The mathematical theory of population genetics (particularly its stochastic aspects) in conjunction with these new developments led us to formulate the "neutral theory" of molecular evolution, pointing out that chance, in the form of random gene frequency drift, is playing a much more important role than previously supposed. I believe that the traditional paradigm of neo-Darwinism needs drastic revision. Also, the importance of gene duplication in evolution, as first
出版日期Book 1980
關(guān)鍵詞Drosophila; Molekulargenetik; antibody; chromosome; evolution; gene; genetics; molecular genetics; populatio
版次1
doihttps://doi.org/10.1007/978-3-642-93138-3
isbn_softcover978-3-540-09998-7
isbn_ebook978-3-642-93138-3Series ISSN 0341-633X Series E-ISSN 2196-9981
issn_series 0341-633X
copyrightSpringer-Verlag Berlin Heidelberg 1980
The information of publication is updating

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Genetic Differentiation of Multigene Families,effective population size of both new and original populations, i. e. the original population has doubled to give the two daughter populations. I shall here apply the simple model of double diffusion. Let us assume that the population and gene family size remain unchanged for a long period, so that
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Statistical Analyses on Sequence Variability of Immunoglobulins,ng because of its enormous diversity within and between species. It will be shown in this chapter that amino acid diversity of variable regions of immunoglobulins fits very well to the prediction of the simple model discussed in the previous chapters.
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Linkage Disequilibrium Between Amino Acid Sites in a Multigene Family,amilies (see page 6 for organization of immunoglobulin genes) is investigated. In the following, the amino acid sites are treated, although the result may be applied to the nucleotide sites. Linkage disequilibrium is the degree of non-random association of amino acids between the two sites in a gene
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Prospects for Future Research,atural selection on the gene diversity contained in the family. It would be preferable to remove such assumptions one by one and to build more realistic models. Many such problems are not solved at the moment and left for future analyses. In this chapter, various unsolved problems are presented. Als
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