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Titlebook: Epitranscriptomics; Stefan Jurga,Jan Barciszewski Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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發(fā)表于 2025-3-21 18:15:32 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Epitranscriptomics
編輯Stefan Jurga,Jan Barciszewski
視頻videohttp://file.papertrans.cn/314/313385/313385.mp4
概述Provides a comprehensive review of the chemical, regulatory, and physiological mechanisms of RNA modification.Unravels the role of RNA modification in development, tissue homeostasis and disease.Revie
叢書(shū)名稱RNA Technologies
圖書(shū)封面Titlebook: Epitranscriptomics; Stefan Jurga,Jan Barciszewski Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp
描述.This book reviews a novel and exciting ?eld of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics...This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. ..Addressing some of the mos
出版日期Book 2021
關(guān)鍵詞Epitranscriptome; RNA methylation; RNA modifications; RNA epigenetics; Neuroepitranscriptome; RNA editing
版次1
doihttps://doi.org/10.1007/978-3-030-71612-7
isbn_softcover978-3-030-71614-1
isbn_ebook978-3-030-71612-7Series ISSN 2197-9731 Series E-ISSN 2197-9758
issn_series 2197-9731
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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Deciphering RNA Methylation in Cancer,vance of these approaches for cancer biology research. We also discuss the potential of third-generation sequencing methods for direct detection of RNA methylation and prospects of RNA methylation for anticancer therapy.
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Roles of m6A RNA Modification in Normal Development and Disease,f a particular gene m.A thus up/downregulates its expression. This mode of gene expression regulation not only is important for normal developmental processes but also plays major roles in disease processes as evidenced by many recently published studies. Abnormal m.A levels and aberrant expression
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發(fā)表于 2025-3-22 13:07:30 | 只看該作者
From m6A to Cap-Adjacent m6Am and their Effects on mRNAs,have been published regarding how cap-adjacent m.Am marks affect their host mRNA. Discrepancies in the data mean that the effects of cap-adjacent m.Am on mRNA stability, decapping, and translation continue to be debated. Finally, while PCIF1 is predominantly nuclear, a subset of results suggests a p
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發(fā)表于 2025-3-22 18:46:55 | 只看該作者
RNA m6A Modification: The Mediator Between Cellular Stresses and Biological Effects,owed RNA modifications responding to other stresses such as starvation, heat shock, and pathogen infection. For instance, heat shock could directly or indirectly affect distribution and abundance of m.A modification, regulated by m.A modifiers, which in turn influenced the expression of specific gen
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ADAR-Mediated RNA Editing and Its Therapeutic Potentials,create a wholesome perspective on the potential of this molecular mechanism as a tool to correct disease-causing G-to-A point mutations. In this context, clinically relevant approaches and their potential future applications, as well as their currently challenging limitations, will be evaluated.
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