Titlebook: Epistasis; Methods and Protocol Jason H. Moore,Scott M. Williams Book 2015 Springer Science+Business Media New York 2015 Modern genetic ana

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Simulation of Functional Mixed Signal Testory-based quantitative methods reveal that levels of pleiotropy and epistasis are in-line with theoretical expectations. The results of the magnified “glaucoma” region of the network confirm the existence of well-documented interactions, supported by overlapping genes and biological pathways and mor

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Epistasis for Quantitative Traits in ,, I review evidence for epistasis in . from the application of these methods, and conclude that additivity is an emergent property of underlying epistatic gene action for . quantitative traits. Such studies can be used to infer novel, highly interconnected genetic networks that are enriched for gene

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Two Rules for the Detection and Quantification of Epistasis and Other Interaction Effects,ale type of the effect measure determines the reference model for defining epistasis. For instance, if effects are measured as differences, then the reference model has to be additive. If the reference effects are fold differences, then the reference model has to be multiplicative. A mathematical ju

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Direct Approach to Modeling Epistasis,genetic effects is based on Fisher’s concept of average excess, which is closely related to the well-known concept of the average effect of a gene substitution. These definitions can be easily extended to cases of two or more loci as long as the loci are independent of each other. Two numerical exam

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Compositional Epistasis: An Epidemiologic Perspective,