Titlebook: Epigenetics in Oncology; Jianjun Chen,G. Greg Wang,Jun Lu Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive licen

ARC

迅速成長(zhǎng)

Inferring the Cancer Cellular Epigenome Heterogeneity via DNA Methylation PatternsTumor cells evolve through space and time, generating genetically and phenotypically diverse cancer cell populations that are continually subjected to the selection pressures of their microenvironment and cancer treatment.

adequate-intake

邊緣

招致

https://doi.org/10.1057/9781137340023s about the dysregulation of epigenetic regulators crucially involved in the initiation, development, and progression of PCa and discuss the potential use of inhibitors targeting epigenetic modifiers for treatment of advanced PCa.

LEVER

ADJ

RNA Modifications in Cancer Stem Cell Biologynt. In this chapter, we summarize the current knowledge of the roles of RNA modifications in shaping the CSC state and driving gene expression programs that confer stem-like properties to CSCs, promote CSC adaptation to the local microenvironment, and endow CSCs with metastatic potential and drug resistance.

Annotate

Epigenetic (De)regulation in Prostate Cancers about the dysregulation of epigenetic regulators crucially involved in the initiation, development, and progression of PCa and discuss the potential use of inhibitors targeting epigenetic modifiers for treatment of advanced PCa.

盡忠

奴才

Histone Readers and Their Roles in Cancerin domains with well-organized three-dimensional structures. In this Chapter, we will outline major histone readers, delineate their biochemical and structural features in histone recognition, and describe how dysregulation of histone readout leads to human cancer.