Titlebook: Epidermal Growth Factor; Methods and Protocol Tarun B. Patel,Paul J. Bertics Book 2006 Humana Press 2006 Activation.Migration.PCR.Vivo.aden

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https://doi.org/10.1007/978-3-319-49619-1uch as the heart, partotid gland, and luteal cells, activation of the epidermal growth factor (EGF) receptor also stimulates second-messenger systems that involve the heterotrimeric G proteins. For instance, in the heart EGF increases contractility and heart rate by elevating cellular cyclic adenosi

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https://doi.org/10.1057/9780230505780 expression is also induced by the epidermal growth factor receptor (EGFR) cascade in some tissues, including the follicle cells of the ovary, the wing, and eye imaginal disc, and acts to abolish mitogen-activated protein (MAP) kinase activated by EGFR signaling. Sprouty is an intracellular protein

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https://doi.org/10.1007/978-3-030-37258-3activation represents the so far best investigated cross-talk mechanism comprising heterogeneous receptor families. In this signaling process G protein-coupled receptor (GPCR) stimulation induces phosphorylation of the EGFR, combining the broad diversity of GPCRs with the potent signaling capacities

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https://doi.org/10.1007/978-981-15-2533-9d molecule at the cell surface. Desensitization of signaling initiates when active receptors are recruited to clathrin-coated regions of the plasma membrane and subsequently sorted to intracellular degradation in lysosomes. Sorting for lysosomal degradation entails receptor conjugation with ubiquiti

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https://doi.org/10.1007/978-3-322-80801-1s followed by their internalization and degradation has, in particular, been extensively studied. This chapter describes the basic methods used to measure ubiquitination and degradation of RTKs using the example of the epidermal growth factor receptor (EGFR). Common sources for endogenous and recomb

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https://doi.org/10.1007/978-3-8350-9505-2y EGF or other high-affinity ligands often results in increased migration of cells in physiological and pathological situations. There are numerous approaches for evaluating cell migratory response following EGF stimulation. Both qualitative and quantitative techniques will be presented in this chap

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