Titlebook: Enzymology and Molecular Biology of Carbonyl Metabolism 6; Henry Weiner,Ronald Lindahl,T. Geoffrey Flynn Book 1997 The Editor(s) (if appli

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In Hepatoma Cell Lines Restored Lipid Peroxidation Affects Cell Viability Inversely to Aldehyde Metcreases their capability to undergo lipid peroxidation (Gravela et al., 1975; Canuto et al., 1991; Cheeseman et al., 1988; Feo et al., 1975; Canuto et al., 1994; Masotti et al., 1988). A consequence of this is the reduced production of aldehydes inside the cells (Poli et al., 1986). Depending on the

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Inhibition of Human Class 3 Aldehyde Dehydrogenase, and Sensitization of Tumor Cells that Express S antineoplastic prodrugs collectively referred to as oxazaphosphorines, e.g., cyclophosphamide, ifosfamide, 4-hydroperoxycyclophosphamide, 4-hydroperoxyifosfamide and mafosfamide (cellular sensitivity to these drugs decreases as cellular levels of ALDH-3 increase) (Sladek, 1993; Sreerama and Sladek,

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Yeast Aldehyde Dehydrogenase Sensitivity to Inhibition by Chlorpropamide Analogues as an Indicator Based on primary structure or subcellular distribution and kinetic, physical and immunochemical properties, they have been placed into one of three classes, viz., class 1, e.g., ALDH-1, class 2, e.g., ALDH-2 and class 3, e.g., ALDH-3 (Anonymous, 1989; Lindahl and Hempel, 1990; Goedde and Agarwal, 1

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Laser Light Scattering and Ultracentrifuge Studies on Sheep Liver Cytosolic Aldehyde Dehdyrogenase,e existence of order of mixing effects led Buckley . (1991) to propose that the tetrameric enzyme was dissociating into an inactive dimer or monomer. Gel filtration studies at pH 7.4 and at pH 5.2 confirmed that dissociation did take place significantly at pH 5.2, with the extent of the dissociation

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