Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald J. Tweedie Book 2014 Springer Science+Busine

河流

Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications,metabolism, kinetics of depletion of substrates (endogenous or exogenous) and formation of metabolites deals with the rate of metabolism. The current textbook specifically focuses on kinetics of drug-metabolizing enzymes, detailing specific enzyme classes, and discusses kinetics as they apply to dru

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Multienzyme Kinetics and Sequential Metabolismt. The second is sequential metabolism, in other words, the formation of multiple products from one CYP enzyme. Given the degree of CYP enzyme promiscuity, it is hardly surprising that there is also a high degree of complex kinetic profiles generated during the catalytic cycle.

Dorsal

Consideration of the Unbound Drug Concentration in Enzyme Kineticsombinant enzyme systems utilized in drug metabolism, each of these has different components that can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kinetic

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misanthrope

Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)es” provides the prospect for more reliable reaction phenotyping and assessment of DDI potential. Although extrapolation of the in vitro intrinsic clearance of a glucuronidated drug often under-predicts in vivo clearance, careful selection of in vitro experimental conditions and inclusion of extrahe

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RAGE

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cortisol