Titlebook: Endothelial Mechanisms of Vasomotor Control; With special Referen H. Drexler,A. M. Zeiher,H. Just Conference proceedings 1991 Dr. Dietrich

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Ganglion

Molecular mechanisms of nitrovasodilator bioactivationof NO-formation correlates with the number of nitrate ester groups and proceeds with a simultaneous nitrite formation (with a ratio of 1: 14 in the presence of cysteine). Nitrosamines such as molsidomine do not need thiol compounds for bioactivation. They directly liberate NO from the ring-open A-fo

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Endothelium-mediated regulation of coronary tonethe double product of heart rate and blood pressure dropped by only 8±2% (p = 0.05). The maximal coronary conductance during peak reactive hyperemia (after 20 s ischemia) indicating complete coronary dilation was diminished by 48% after .-NNA..The severe drop in resting myocardial perfusion and O.-s

Prologue

Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide vascular resistance and abolition of the increase in platelet cGMP induced by intraarterial infusion of acetylcholine. In addition, the oxygen uptake of the hindlimb (?46%) and the skeletal muscle pO. were significantly reduced. It is concluded that continuously released EDRF has a functional role

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dura-mater

Conference proceedings 1991 as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endothelial Mechanisms of Vasomotor Control, clearly is of interest for both basic scientists and clinicians. It has been the aim of the organizers, the S