Titlebook: Endolysosomal Voltage-Dependent Cation Channels; Christian Wahl-Schott,Martin Biel Book 2023 Springer Nature Switzerland AG 2023 Endo-lyso

合群

Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/e/image/309817.jpg

灌溉

https://doi.org/10.1007/978-3-540-89042-3meable to Ca. and Na. and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P. and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.

aptitude

Endo-Lysosomal Two-Pore Channels and Their Protein Partnersmeable to Ca. and Na. and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P. and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.

Inkling

NAADP-Mediated Ca2+ Signallingto our?understanding of Ca. signalling, not least in providing a link between cell stimulation and Ca. release from lysosomes and other acidic Ca. storage organelles. In addition, the hallmark concentration-response relationship of NAADP-mediated Ca. release, shaped by striking activation/desensitiz

雜色

NAADP-Dependent TPC Currentlian cells. These channels have been implicated in Ca. signaling initiated from the endolysosomes, vesicular trafficking, cellular metabolism, macropinocytosis, and viral infection. Although TPCs have been shown to mediate Ca. release from acidic organelles in response to NAADP (nicotinic acid adeni

beta-cells

NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axislism and Ca. mobilizing activity of NAADP are reviewed, with emphasis on a novel redox cycle between the inactive reduced form, NAADPH, and the active oxidized form, NAADP. Oxidation from NAADPH to NAADP is catalyzed in cell free system by (dual) NADPH oxidases NOX5, DUOX1, and DUOX2, whereas reduct

cathartic

TPC Functions in the Immune System In this chapter, we focus on their function in immune cells and immune reactions. Therefore, we first give an overview of the cellular immune response and the partaking immune cells. Second, we concentrate on ion channels which in the past have been shown to play an important role in the regulation

LANCE

Lysosomal Ion Channels and Lysosome–Organelle Interactionstes (MCSs) with ER and mitochondria, lysosomes mediate bidirectional transport of metabolites and ions between lysosomes and organelles that regulate lysosomal physiology, movement, membrane remodeling, and membrane repair. In this chapter, we will first summarize the current knowledge of lysosomal

carbohydrate

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Lysosomal Potassium Channelsmitophagy, and autophagy. To function properly, intralysosomal environments are strictly controlled by a set of integral membrane proteins such as ion channels and transporters. Potassium ion (K.) channels are a large and diverse family of membrane proteins that control K. flux across both the plasm