Titlebook: Drug‘DNA Interaction Protocols; Keith R. Fox Book 19971st edition Humana Press 1997

高談闊論

,A Gel Mobility Shift Assay for Probing the Effect of Drug–DNA Adducts on DNA-Binding Proteins,rizing drug-DNA interactions is to ascertain the ability of DNA binding proteins to recognize then drug-modified DNA consensus sequences (.–.). This approach is particularly relevant because such 5′untranslated regions are unwound when assembled on the nuclear matrix and thus accessrble to drugs dur

GENRE

Determination of the DNA Sequence Specificity of Alkylation Damage Using Cleavage-Based Assays, which show a limited discrimination between the target base in different sequence contexts, to those such as CC-1065 and talhinustine, which show a high degree of selectivity to certain unique sequences, with the corresponding avoidance of others.

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Book 19971st edition experimental techniques or to improve their current techniques will also find these powerful methods particularly helpful in elucidating the action of existing therapeutic agents, as well as in designing new anticancer drugs with improved action and reduced toxicity. .......