Titlebook: Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities; Awanish Mishra,Hitesh Kulhari Book 2023 The Editor(s) (i

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https://doi.org/10.1007/978-3-662-36243-3ivery process. The BBB is a constituent of the neurovascular unit. It comprises neurons, astrocytes, microglia, a basement membrane, and a layer of microvascular endothelial cells around the brain that protect the same. It maintains the right ionic balance within the brain and blocks the substances

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https://doi.org/10.1007/978-3-662-36243-3dity and mortality. The presence of blood–cerebrospinal fluid (B-CSF) and blood–brain barrier (BBB) causes attenuation of site-specific delivery of therapeutic agents in neurodegenerative disorders. Since last decade, nanocarriers such as liposomes, nanoparticles (NPs), nano emulsions, dendrimers, a

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https://doi.org/10.1007/978-3-662-36243-3his imbalance is the alteration of excitatory and inhibitory neurotransmitter settings. In particular, the inhibition of GABA neurotransmitters during seizures does not occur, which is expected to occur in a healthy state of neurons. Another situation is that excitatory glutamate neurotransmitters c

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https://doi.org/10.1007/978-3-662-36243-3ge. This review outlines key mechanisms, including excitotoxicity, inflammation, oxidative stress, and disrupted blood-brain barrier integrity. Furthermore, it underscores the importance of tailored management approaches that encompass acute medical interventions, and various neuroprotective agents.

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https://doi.org/10.1007/978-3-662-36275-4rative disease. The characteristic feature of HD is mutation in the HTT gene which is located on chromosome 4 which leads to expansion of CAG repeat, causing neurodegeneration of striatum and cortex of brain. Along with genetic predisposition other molecular mechanism such as excitotoxicity, dopamin