Titlebook: Dermal Drug Selection and Development; An Industrial Perspe Lionel Trottet,Howard Maibach, MD Book 2017 Springer International Publishing A

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Topical Vehicle Selection: Myths and Reality,risk of not engaging the target. Indeed to increase comfort that the target will be engaged one need to try fullfill as best as it can evidence of (1) sufficient compound on board for a desired time (i.e., PK within skin) and (2) demonstration of pharmacological activity [1].

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Modern Voluntarist Views of Faithhe molecular basis of diseases as well as the push from payors to deliver better medicines compared to standard of care. This presents a strong opportunity for pharma companies who want to invest into dermal drug development projects as more assets and more therapeutic targets are becoming available

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https://doi.org/10.1007/978-1-349-19036-2otations and rules are listed in this chapter. Extra comments met during the course of various topical drug development programs are added too. Overall these quotations and rules, sometimes considered provocative, may be found helpful for program teams developing a topical molecule.