Titlebook: Damage-Associated Molecular Patternsin Human Diseases; Volume 2: Danger Sig Walter Gottlieb Land Book 2020 Springer Nature Switzerland AG 2

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The “DAMPome” as a Key Player in the Pathogenesis of Human Diseasestiate a disorder. In fact, a disturbed DAMP:SAMP ratio may even be the pathogenetic key event in instigating a human disease. Logically, if one defines a disturbed homeostatic DAMPs:SAMPs ratio upon cell stress/tissue injury as the pathogenetic principle in human diseases, therapeutic efforts should

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The Growing World of DAMPslassification of DAMPs as chosen in Vol. 1 is maintained but slightly modified. Thus, four DAMPs categories are defined, termed as (I) endogenous constitutively expressed native DAMPs; (II) endogenous constitutively expressed, injury-modified DAMPs; (III) endogenous inducible DAMPs produced by previ

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