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Titlebook: DNA Topoisomerases and Cancer; Yves Pommier Book 2012 Springer Science+Business Media, LLC 2012 Tyrosyl-DNA-Phosphodiesterase.Ubiquitin.an

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書目名稱DNA Topoisomerases and Cancer
編輯Yves Pommier
視頻videohttp://file.papertrans.cn/261/260203/260203.mp4
概述Structure and mechanism of eukaryotic type IIA topoisomerases.DNA topoisomerase I and illegitimate recombination.Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents
叢書名稱Cancer Drug Discovery and Development
圖書封面Titlebook: DNA Topoisomerases and Cancer;  Yves Pommier Book 2012 Springer Science+Business Media, LLC 2012 Tyrosyl-DNA-Phosphodiesterase.Ubiquitin.an
描述.DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action..
出版日期Book 2012
關(guān)鍵詞Tyrosyl-DNA-Phosphodiesterase; Ubiquitin; antigens; camptothecins; transcriptional stress
版次1
doihttps://doi.org/10.1007/978-1-4614-0323-4
isbn_softcover978-1-4614-2963-0
isbn_ebook978-1-4614-0323-4Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer Science+Business Media, LLC 2012
The information of publication is updating

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Structure and Mechanism of Eukaryotic Type IIA Topoisomerases,rried out by an ATP-dependent, duplex strand-passage mechanism that relies on the transient and reversible enzyme-mediated cleavage of DNA. A wealth of biochemical and structural data on Top2 (topo II), the eukaryotic member of this topoisomerase family, as well as complementary studies on its bacte
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Topoisomerase-Induced DNA Damage,o DNA structure. Here, we will review how topoisomerases can damage the genome when it contains preexisting DNA lesions at the enzyme sites of action. This brief chapter gives an overview of the broad range of lesions that lead to the accumulation of cleavage complexes produced by DNA topoisomerases
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