Titlebook: D-type Cyclins and Cancer; Philip W. Hinds,Nelson E. Brown Book 2018 Springer International Publishing AG 2018 D1-S transition.cyclin prot

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D-Type Cyclins and Gene Transcription,f coactivators, the modulation of transcription factor binding in the context of chromatin, and their ability to serve as molecular scaffolds that facilitate the interactions between chromatin-modifying enzymes (histone and DNA methylases [Suv39, HP1., G9a, DNMT1, PRMT1], histone acetylases [SRC1, p

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Mammalian Development and Cancer: A Brief History of Mice Lacking D-Type Cyclins or CDK4/CDK6,Ks), the activity of which is necessary to drive each phase of the cell cycle. Mitogenic stimulation leads to the expression of D cyclins which bind and activate CDK4 and CDK6. This event triggers a chain of events ultimately leading to cell division. Dissection of the functions of D cyclins and CDK

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Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis, an active protein kinase. The D-type cyclin/CDK kinase coordinates G1 progression in response to growth factor signaling. The cyclin D/CDK4 or CDK6 kinase is the first cyclin/CDK complex to be activated in mammalian cells during G1/S transition. While the three D-type cyclins are almost indistingui

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Cyclin D1, Metabolism, and the Autophagy-Senescence Balance,fferentiate. Not surprisingly, deregulation of the G1/S transition is a well-established hallmark of cancer. While the basic mechanisms involved in this transition have been extensively characterized, it is now evident that components of the core cell cycle machinery, including cyclin D1, are functi

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