Titlebook: Cyclin Dependent Kinase (CDK) Inhibitors; Peter K. Vogt,Steven I. Reed Book 1998 The Editor(s) (if applicable) and The Author(s), under ex

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Access, Stents, and Urinary Drainage1 and they are increasing at a rate of up to 25 per week. The p53 field which dates back to 1979 has had some 6000 references on Medline since 1993. This chapter will highlight some of the recent discoveries emphasizing the role of p21 and p53 in growth control and the maintenance of genomic integrity.

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Cyclin-Dependent Kinase Inhibitors of , and , ,derstand about eukaryotic cell division derives from studies in these organisms. Cyclin-dependent protein kinase (CDK) inhibitors (CKI), the focus of this volume, were first described in yeast, and yeast is still the best system for dissecting out the complex in vivo relationships between the CKI an

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Inhibitors of the Cip/Kip Family,zed to date, fundamental mysteries remain concerning their biological roles and their regulation. The family, consisting so far of three members, is characterized by a C-terminal Cdk-inhibitory domain with a shared core homology and unrelated C-terminal domains of varying size (. et al. 1995; . et a

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Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development,nated manner (. et al. 1995; . and . 1995; . et al. 1996). Various mitogens, growth factors, cytokines, and a host of other agents can perturb the cell cycle machinery eliciting proliferation, differentiation, or apoptosis (. et al. 1994; . 1994). Any permanent alteration of the cell cycle-regulator

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Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice,ng to the development of sophisticated vector systems, in combination with the establishment of mouse embryonic stem (ES) cells, targeted mutagenesis of a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches usin

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