Titlebook: Current Directions in Insulin-Like Growth Factor Research; Derek Roith,Mohan K. Raizada Book 1993 The Editor(s) (if applicable) and The Au

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IRR: A Novel Member of the Insulin Receptor Family, a cytoplasmic tyrosine kinase activated by insulin binding (Ebina et al., 1985; Ullrich et al., 1985; Ullrich et al., 1986). The α-and β-subunits are derived by proteolytic cleavage of the proreceptor.

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Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid andse activity of the receptors appears to be essential. These tyrosine kinases are highly homologous and differences in signalling capacities of the IR and IGFR in a given cell background have not been clearly defined.