Titlebook: Control of Gene Expression by Catecholamines and the Renin-Angiotensin System; Heinz Rupp,Bernard Maisch Book 2000 Springer Science+Busine

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Control of Gene Expression by Catecholamines and the Renin-Angiotensin System

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Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREBiption factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context-and position-s

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Transcriptional regulation by cAMP in the heartrce in the heart. In addition to this, long-term β-adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an importan

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Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor familynsfected with a dominant negative construct of CREB, KCREB. KCREB has a mutation in its DNA-binding domain and can not bind the CRE element. Expression of KCREB yields proper heterodimerization with CREB and its associated proteins, but the proteins associated with KCREB do not confer the same degre

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