Titlebook: Connexin Hemichannels; Methods and Protocol Fabio Mammano,Mauricio Retamal Book 2024 The Editor(s) (if applicable) and The Author(s), under

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https://doi.org/10.1007/978-1-0716-3842-2membrane proteins; bacteria; exosomes; cellular physiology; ATP release

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Mordechai Feingold,Victor Navarro-Brotons-head docking of hemichannels (each from one of two adjacent cells). Free “undocked” hemichannels at the plasma membrane are mostly closed, although they are still important under physiological conditions. However, abnormal and sustained increase in hemichannel activity due to connexin mutations or

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Frank A. G. den Butter,Marjan W. Hofkes level. They offer possibilities that are often unavailable to experimental methods, making MD an ideal complementary technique for the understanding a plethora of biological processes. Thanks to significant efforts by many groups of developers around the world, setting up and running MD simulations

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https://doi.org/10.1007/1-4020-4418-6ing intercellular channels. These large-pore channels are dynamic and typically have a short life span of only a few hours. Imaging connexins from the time of synthesis in the endoplasmic reticulum through to their degradation can be challenging given their distinct assembly states and transient res

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Roque Corral,Nélida Cerezal,Cárlos Vasco support intercellular communication mechanisms and regulate homeostasis. In contrast, open connexin hemichannels connect the intracellular compartment and the extracellular environment, and their activation fuels inflammation and cell death. The development of clinically applicable connexin hemicha

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Junichi Kazawa,Toshinori Watanabey several protein families with little or no evolutionary linkages that include connexins (Cxs), pannexins (Panxs), innexins (Inxs), CALHM1, and LRRC8 proteins. Recently, we have described the unnexins (Unxs) proteins expressed in . (.) that also is like to form large-pore channels at the plasma mem