Titlebook: Chromosome Translocation; Yu Zhang Book 2018 Springer Nature Singapore Pte Ltd. 2018 Cancer.Chromosome Translocation.DNA repair.Genome Org

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Andromachi Tseloni,Rebecca Thompsonut also in repair efficiency, likelihood of DNA damage, and the biological implications of translocations. This chapter focuses on our current understanding of the role of 3D genome structure in chromosome translocation formation and its potential implications in disease outcome.

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A Framework for Modelling Productionial distribution of the constituting energy deposition events, also called track structure, the sources of local genomic shattering underpinning chromothripsis are under investigation. Notably, many consequences of DSB clusters in the affected genome reflect processing by pathways that have evolved

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Historical and Clinical Perspectives on Chromosomal Translocations,loinsufficient genes or their regulatory regions and result in clinical phenotypes. Balanced translocations from patients with clinical phenotypes have been valuable in mapping disease genes and in illuminating .-regulatory regions. Mapping of discordant mate pairs from long-insert, low-pass genome

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3D Genome Organization Influences the Chromosome Translocation Pattern,ut also in repair efficiency, likelihood of DNA damage, and the biological implications of translocations. This chapter focuses on our current understanding of the role of 3D genome structure in chromosome translocation formation and its potential implications in disease outcome.

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Book 2018f chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases..The book also introduces the mechanistic studies on chromosome deletions and their i

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0065-2598 chromosome translocations.Contributions from experts in the.This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing tec