Titlebook: Chemogenomics; Methods and Protocol Daniel Merk,Apirat Chaikuad Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive

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Developing a Kinase Chemogenomic Set: Facilitating Investigation into Kinase Biology by Linking Phes that drive novel biology. Additionally, the associated data deposited in the public domain have also been used to inform new inhibitor design. Further expansion of this set to complete kinome coverage will allow for a greater understanding of kinase biology and its role in disease.

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Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein el to identify small-molecule STEP inhibitors, we have developed a cellular target engagement assay that can identify compounds that interact with STEP.. We provide a comprehensive protocol to enable the use of this miniaturized assay, and we demonstrate its utility to benchmark the binding of newly discovered compounds.

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