Titlebook: Cell-Wide Identification of Metabolite-Protein Interactions; Aleksandra Skirycz,Marcin Luzarowski,Jennifer C. E Book 2023 The Editor(s) (i

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壓艙物

https://doi.org/10.1007/978-3-319-66920-5nges in the protein thermal stability caused by the interactions with small molecules at the proteome level. Here we describe the small-molecule target validation as well as the target identification with mass spectrometry by means of CETSA.

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ALIAS

https://doi.org/10.1007/978-3-319-66920-5nce to solvent-induced precipitation. This chapter describes the protocol for identifying drug–target protein interactions by performing unbiased SIP with total cell lysate using a mass spectrometry-based proteomic strategy.

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Book 2023 and practical, .Cell-Wide Identification of Metabolite-Protein Interactions. will aid researchers seeking a better understanding of the mechanisms of signal transduction occurring in the cell and assessing the effect of complex formation on cell physiology..

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Application: Nitrate Reduction Processes,e. PISA dramatically reduces analysis costs, allowing many research questions in need of target deconvolution to be addressed, and unlocks the potential of miniaturizing biological models, including primary cells.

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