Titlebook: Cell Cycle Deregulation in Cancer; Greg H. Enders Book 2010 Springer Science+Business Media, LLC 2010 DNA.biology.cancer.cancer therapy.ce

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https://doi.org/10.1007/978-1-4419-1770-6DNA; biology; cancer; cancer therapy; cell; esophagus; research; senescence; tumor; tumorigenesis

Brochure

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Greg H. Endersoutlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy..Includes supplementary material:

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menopause

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https://doi.org/10.1007/978-94-017-6766-8Furthermore, deregulation of pre-RC components and CDK/cyclins is observed in a multitude of human cancers. Thus, regulation of pre-RC assembly is a critical facet of normal cell biology that has profound implications related to cancer etiology and diagnosis.

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The Senescence Secretome and Its Impact on Tumor Suppression and Cancers includes increased production of cytokines, matrix metalloproteases, and altered production of many growth factors. This review discusses these factors, their mechanism of regulation in senescent cells, and their contribution to the senescent phenotype and its role in tumor suppression.

口味

https://doi.org/10.1007/978-94-017-7127-6kpoints. Failure of cells to undergo mitotic catastrophe is believed to contribute to tumorigenesis. Furthermore, mitotic catastrophe is exploited as a strategy to induce cell death in cancer treatments.