Titlebook: Cardiac Metabolism in Health and Disease; Salah Abdel-Aleem,James E. Lowe Book 1998 Springer Science+Business Media Dordrecht 1998 ATP.Gly

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Identification of nucleoside transport binding sites in the human myocardium,kers. However, clinical application of nucleoside transport inhibitors remains to be demonstrated in humans. It is not known whether human heart has nucleoside transport similar to that of animals. The aim of this study is to pharmacologically identify the presence of nucleoside transport binding si

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Mutagenesis and characterization of specific residues in fatty acid ethyl ester synthase: A gene fotion to site specific mutagenesis. In this study, three residues (Gly 32, Cys 39 and His 72) have been mutated to observe their role in enzyme activity. Gly to Gln, Cys to Trp and His to Ser mutations did not affect fatty acid ethyl ester synthase activity, but His to Ser mutant had less than 9% of

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Palmitate oxidation by the mitochondria from volume-overloaded rat hearts,aded rat hearts. The most significant data are the following: (1) The slowing down of long-chain fatty acid oxidation in severely hypertrophied hearts cannot be related to a feedback inhibition of carnitine palmitoyltransferase I from an excessive stimulation of glucose oxidation since, because of d

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Effects of phosphodiesterase inhibitors on glucose utilization in isolated cardiac myocytes,oupled and inversely related in cardiac tissue to fatty acid oxidation, this study was designed to investigate enoximone’s effects on glucose metabolism in the heart. To determine if enoximone alters this reciprocal relationship, the effects of enoximone on [U-.C]glucose and [2-.C]pyruvate oxidation

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The liver isoform of carnitine palmitoyltransferase I is activated in neonatal rat cardiac myocytesy. Neonatal cardiac myocytes in culture respond to hypoxia/serum-and glucose-free medium by a slow decline in ATP which reverses upon oxygenation. This model was employed to examine whether carnitine palmitoyltransferase I (CPT-I) modulates high rates of β-oxidation following oxygen deprivation. Aft

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Human myocardial ATP content and , contractile function,ine nucleotides, and NAD were quantified in human myocardial biopsies using high performance liquid chromatography. Right ventricular endomyocardial biopsies were obtained from 43 patients with dilated cardiomyopathy, 6 with restrictive cardiomyopathy, 10 with normal systolic and diastolic function,

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