Titlebook: Cardiac Fibrosis and Heart Failure: Cause or Effect?; Ian M.C. Dixon,Jeffrey T. Wigle Book 2015 Springer International Publishing Switzerl

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Natriuretic Peptides: Critical Regulators of Cardiac Fibroblasts and the Extracellular Matrix in thg these is the ability to prevent fibroblast proliferation and abnormal collagen deposition in the ECM. NPs elicit their effects by binding to three NP receptors denoted NPR-A, NPR-B and NPR-C. NPR-A and NPR-B are guanylyl cyclase-linked NPRs that elicit their effects by increasing cGMP levels. NPR-

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Cardiac Fibrosis and Heart Failure: Cause or Effect?

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978-3-319-37995-1Springer International Publishing Switzerland 2015

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Cardiac Fibrosis and Heart Failure: Cause or Effect?978-3-319-17437-2Series ISSN 2512-2142 Series E-ISSN 2512-2150

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Homegeneity Testing for Covariance Matrices,recent advances in our understanding have allowed us to identify cardiac fibrosis as a primary disease independent of either cardiomyocyte injury or loss. New developments within this field are burgeoning, including research that points to multiple sources for cardiac myofibroblasts participating in

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https://doi.org/10.1007/0-387-29053-2ronment results in multiple homeostatic mechanisms, but also a wide variety of putative disease pathways by which valve function can be compromised. Aortic valve disease (AVD) is a cell-mediated pathology whose initial stages are characterized by unchecked matrix dysregulation, leaflet thickening, a