Titlebook: Captopril and Hypertension; David B. Case,Edmund H. Sonnenblick,John H. Laragh Book 1980 Springer Science+Business Media New York 1980 blo

NAG

Physiological, Biochemical, and Immunologic Aspects of Angiotensin-Converting Enzymetes.. It was first detected by Skeggs et al.. who found that the product of the action of porcine renin on crude equine angiotensinogen could be resolved into two compounds, provided the incubation was carried out in the presence of chloride ions. Subsequently,. they established that this was due to

密切關(guān)系

總

Captopril (Capoten?; SQ 14,225) (,-3-Mercapto-2-methylpropanoyl-,-proline)-converting enzyme (ACE) [E.C. 3.4.15.1] has also been designated as converting enzyme (CE), peptidyldipeptide carboxy hydrolase, kininase II, or “bradykininase.” Hence, in vivo inhibition of ACE will reduce the pressor activity of AI, but not that of AII, and augment the vasodepressor activity of b

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Toxicologic and Drug Metabolic Studies of SQ 14,225 in Animalsbin et al. in other chapters in this volume. This chapter will delineate the results of a number of studies that characterized the acute and subacute toxicities of SQ 14,225 in laboratory animals. Some metabolic data from preliminary studies in rats and dogs are also included.

從屬

Captoprilst be administered parenterally, which makes chronic blockade of the system practically impossible. Furthermore, saralasin, a competitive inhibitor of the active hormone angiotensin II, has the disadvantage of inherent agonistic properties.. On the other hand, because angiotensin-converting enzyme i

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身心疲憊

exhibit

The Use of SQ 20,881 Converting Enzyme Inhibitor (Teprotide) for Diagnostic Purposes in Hypertension. There is little doubt that renin profiling is helpful in detecting the few surgically curable forms of hypertension. However, since it was suggested. that the levels of plasma renin activity can serve as a guide to tailor specific medical treatment for a particular patient, the interest in profili

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Clinical Experience with Blockade of the Renin-Angiotensin-Aldosterone System by an Oral Converting ncreasing recognition that pharmacological inhibition of the system can be a potent mechanism by which blood pressure can be lowered. Bühler and coworkers,. in examining the renin-lowering effect of β-adrenergic blockade in patients with essential and malignant hypertension, found that propranolol i

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