Titlebook: Cancer Genes; Functional Aspects Enrico Mihich,David Housman Book 1996 Springer Science+Business Media New York 1996 apoptosis.cancer.cell.

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The , Gene and Human Leukemias,pathogenesis of hematologic malignancy by virtue of involvement in translocation breakpoints include the PML-RARa fusion associated with t(15;17) acute promyelocytic leukemia (APML, refs. 1–3), the AML1-ETO fusion associated with t(8;21) acute myeloid leukemia (AML, ref.4), the CBF?-MYHII fusion ass

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Selective Killing of BCR-ABL Positive Cells with a Specific Inhibitor of the ABL Tyrosine Kinase,an annual incidence of between 1 to 2 cases per 100,000 persons per year. The median age of onset is approximately 50 years of age. Clinically, the disease is characterized by a chronic phase in which the only apparent abnormality is the massive expansion of functionally normal myeloid lineage cells

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