Titlebook: Cancer Driver Genes; Methods and Protocol Timothy K. Starr Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 thr

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KARMEN: Neutrino Physics at ISIS. In this protocol we describe a method of chromosomal engineering in mice that allows modeling of chromosomal duplications and deficiencies. This method faithfully recapitulates several aspects of chromosomal loss and gain in human cancers and can reveal cancer drivers difficult to identify by other means.

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Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Linese monitored over time through high-throughput sequencing of the integrated sgRNA expression cassettes. Using this technique, we outline strategies for the identification of cancer driver genes and genes mediating drug response.

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1064-3745 ation advice from the experts.This book presents protocols for identification of genetic drivers of cancer. Chapters guide readers through a brief history of cancer gene discovery,?.in silico.?approaches,?.in vitro.?approaches, and?.in vivo.?approaches using forward genetic screens in mice.?Written

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