Titlebook: CPP, Cell-Penetrating Peptides; ülo Langel Book 2023Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive licens

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https://doi.org/10.1007/978-981-15-2113-3This Chapter summarizes the methods for CPP-conjugated oligonucleotide-based agents with the potential to use as the therapeutic drugs. The methods for gene silencing (or inhibiting specific genes) using antisense ONs (ASO) and RNA interference (RNAi) are summarized.

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Nature, Environment and SocietyThe multiple examples of the strategies of the use of CPPs to shuttle the proteins and protein mimics and their targeting are summarized in this Chapter.

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https://doi.org/10.1007/978-94-009-1878-8In this Chapter, the targeting strategies of CPP and CPP/cargo complexes to specific cells or intracellular organelles are summarized, and their potential for pharmacological or clinical use is briefly discussed.

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Cultural Metaphors Related to R,In this Chapter, a brief summary of the clinical trials and commercialization attempts using the CPP approaches for the delivery of pharmaceuticals is presented. An attempt has been made to include the information concerning the initiation and finalization of clinical trials by different companies.