Titlebook: Biophysics of Infection; Mark C. Leake Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Natu

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Designing a Single-Molecule Biophysics Tool for Characterising DNA Damage for Techniques that Kill ong with the optical requirements for how to implement these into a light microscopy imaging system capable of single-molecule millisecond timescale imaging. This system promises significant improvements in reproducibility of the quantification of DNA damage over traditional techniques.

Cerebrovascular

Bugs on a Slippery Plane,ons for flows in a thin film with general slip boundary conditions, and establish connections between theoretical and experimental results. This article aims to highlight the importance of mathematics as a tool to unlock qualitative mechanisms associated with experimental observations in the medical and biological sciences.

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https://doi.org/10.1057/9780230625259indicators provide valuable information on bacterial studies. These new biophysical techniques allow us to monitor the protonmotive force even in single bacterial cell level that shed the light of next generation single-cell physiological experiments towards the understanding of bacterial infection process.

RAGE

https://doi.org/10.1007/978-1-349-18629-7of the sigma54-dependent Phage shock protein (Psp) system—a major stress response when Gram-negative pathogens encounter damages to their inner membranes. We discuss the recent development on mechanisms of gene regulation, signal transduction and stress mitigation in light of different biophysical and biochemical approaches.

CLASH

Single-Molecule Observation of DNA Replication Repair Pathways in ,,fy the amount of operator at the block and simultaneously image fluorescently labelled DNA polymerase. We anticipate use of this system as a quantitative platform to study replication stalling and repair proteins.

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