Titlebook: Biopharmaceutical Manufacturing; Progress, Trends and Ralf P?rtner Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusi

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Vascular Lesions: Port Wine Stains advancements in the development of these systems. One of the most notable developments in bioprocess monitoring systems is the use of biosensors, which can detect and measure biological molecules such as enzymes and proteins. The use of imaging technologies, such as microscopy and flow cytometry, h

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https://doi.org/10.1007/978-3-642-95780-2 of uses. This book chapter provides an overview of the main characterization methods for aerated stirred tank reactors in the context of cell culture processes. The methods described include mechanical power input, volumetric mass transfer, flow field, and mixing characterization. Examples are give

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Entwicklung der Planungsmethode,bring is attractive and inclusion of perfusion process is nowadays often envisioned for a switch towards continuous processing including downstream, for an intensification only in the upstream production process or for the intensification at the level of the seed bioreactor only. In all cases, the i

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Laserchirurgie der Gesichtshaut,reasing equipment footprint and increase equipment utilization. For the interested reader this chapter provides an overview over the main developments in continuous downstream processing of biopharmaceuticals and introduces the main unit operations such as continuous chromatography, continuous filtr

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https://doi.org/10.1007/978-3-642-56734-6opharmaceutical manufacturing field. The realization of DT could help reduce cost, improve productivity, maintain high and constant product quality, and meet Quality-by-Design (QbD) guidelines. Nonetheless, the development of DT is still at its infancy stage and an integrated DT in biopharma is rare

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Diode-Laser Sensors for In-Situ Gas Analysisg genes, cells, or tissues. Owing to their promising clinical outcomes in the treatment of rare and life-threatening diseases, ATMPs, have been gaining increasing interest from the global scientific and industrial community. The rapid growth in the demand for ATMPs is challenging manufacturers who a

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F. Lewitzka,M. Niederkrüger,G. Marowskyoncept of QbD is that the development of a therapeutic protein starts with the comprehensive understanding of the target product profile in terms of identity, strength, quality, purity, and potency. The manufacturing is then designed to ensure the product produced from the designed process meet the

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