Titlebook: Biologics to Treat Substance Use Disorders; Vaccines, Monoclonal Ivan D. Montoya Book 2016 Springer International Publishing Switzerland 20

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Therapeutic Vaccines for Treating Nicotine Addictionof progress. A report of the Surgeon General, 2014). The Centers for Disease Control estimates that the direct healthcare costs attributable to treating smoking and smoking-attributable illness exceed $170 billion per year (CDC, Smoking & Tobacco Use: Fast Facts, 2015). Only one in five smokers achi

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Cocaine and HIV Infection in the United States, and PWID are incontrovertibly at risk for HIV acquisition (Friedman et al. 1989). In addition, there are many other complex direct and indirect associations in different populations between cocaine use and HIV infection. Cocaine use is associated in various contexts with a gre

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Anti-cocaine Monoclonal Antibodiess have many advantages as an immunotherapy for cocaine abuse, the use of anti-cocaine mAbs addresses the limitations of cocaine vaccines: the polyclonal response that produces between-patient variability of affinities of the antibodies raised, the amount of antibodies raised, and the delay in the pr

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Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamper than a direct action in the brain, the mAb medication binds METH with high affinity in the bloodstream leading to a reduction and slowing of METH brain penetration. Through an extensive discovery and development process, prototype mouse anti-METH mAb medications were selected and tested in precli