Titlebook: Biological Reactive Intermediates—II; Chemical Mechanisms Robert Snyder,David J. Jollow,Stephen L. Longacre Book 1982 The Editor(s) (if ap

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Interlocking

Manfred Wick,Wulf Pinggera,Paul Lehmann chemicals is seen only after metabolic activation of the original chemical to a more toxic form. Several lines of evidence indicate that benzene also must be metabolically activated in order to exert its characteristic toxicity on bone marrow. Most of the hydroxylated benzene metabolites known toda

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deactivate

,Bestimmungsmethoden für Elektrolyte,(Koch-Weser et al., 1953; Reid et al., 1971). Metabolic activation of bromobenzene to reactive intermediate(s) by the cytochrome P-450-linked monooxygenase system is required for this agent to produce liver damage which, in turn, is preceded by depletion of hepatic glutathione (GSH) (Jollow et al.,

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Fate of Epdxidesbe the primary lesion ultimately leading to initiation of cancer (Miller and Miller, 1974; Oesch, 1973; Jerina and Daly, 1974; Sims and Grover, 1974; Heidelberger, 1975; Gelboin et al., 1972). This review first describes structure-activity relationships for the mutagenicity of some epoxides and then

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