Titlebook: Biological Reactive Intermediates V; Basic Mechanistic Re Robert Snyder,I. Glenn Sipes,Charlotte M. Witmer Book 1996 The Editor(s) (if appl

ablate

An Oxidant Sensor at the Plasma Membraner-specific recognition elements, the growth factors induce, through their cell surface receptors, a complex process of signal transduction to the nucleus (for reviews see Beato, 1989; Karin, 1994; Gilbert, 1994; Angel and Herrlich, 1994; McCormick, 1995; Howe and Weiss, 1995; Ullrich and Simon, 1995).

endocardium

Reactive Dopamine Metabolites and Neurotoxicitygid et al., 1993). There is also growing evidence that endogenous factors such as oxidative stress and DA itself may contribute to the neurodegenerative process (Cohen, 1983; Agid et al., 1993; Zigmond et al., 1992).

蛛絲

Book 1996try is replete with exam- ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive

moratorium

厚顏無(wú)恥

阻止

有其法作用

Oratory

喃喃訴苦

Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-,]Purinear basis for the genotoxic effects of the parent compound, and site specific mutagenesis studies (Basu et al., 1993) show its mutagenicity. There is evidence that ε adducts might not only be formed by vinyl chloride metabolites but also be present at a certain level due to endogeneous sources (Misra et al., 1994).

蒸發(fā)

Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzenet al., 1971). Both 1,2-dichlorobenzene and its 1,4-isomer are metabolized by cytochrome P450 enzymes to an epoxide intermediate. This epoxide may either rearrange to produce phenols, hydrolyse to form dihydrodiols or conjugate with glutathione.