Titlebook: Biological Reactive Intermediates IV; Molecular and Cellul Charlotte M. Witmer,Robert R. Snyder,I. Glenn Sipe Book 1991 The Editor(s) (if a

CURT

https://doi.org/10.1007/978-3-662-41617-4tations and gene rearrangements are involved in causing one or more of the required changes. However, the molecular mechanisms by which carcinogens induce such changes in mammalian cells are not well understood. One reason for this has been the difficulty involved in sequencing the newly mutated gen

先驅

Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediatese has been accrued over the years to support the view that the majority of chemical carcinogens require bioactivation in order to elicit tumor initiation, and many toxic chemicals other than carcinogens also require bioactivation. The P-450 enzymes are probably involved to a greater extent than any

Omniscient

Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactioechanism for the termination of drug action. Metabolism may quantitatively alter drug action and may also convert pharmacologically inactive prodrugs to their pharmacologically active metabolites. In addition, metabolism of xenobiotics to polar, readily excretable metabolites is a major detoxication

fledged

Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Contro initially believed to serve as intracellular transport proteins for endogenous compounds with limited solubility in water, thereby acting as an intracellular equivalent to albumin. In this assumed capacity of reversible binding and transport of various ligands, the corresponding protein was named l

戰(zhàn)役

Osteoporosis

觀點

Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damve Intermediates III (Wefers and Sies, 1986), work from our laboratory has been presented comprehensively (Sies, 1986, 1988; Ishikawa and Sies, 1989). Further, the biochemistry of oxygen toxicity has been presented (Cadenas, 1989).

In-Situ

弄污

cogitate

S-Thiolation of Protein Sulfhydryls“reactive” sulfhydryl are prevelant in cytoplasm, membranes, and nuclei, and the concentration of these reactive sites is impressive, reaching or exceeding the concentration of glutathione in many cells. Most proteins contain a single reactive sulfhydryl and are unlikely to form protein-protein disu