Titlebook: Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances; Proceedings of the E Philip L. Chambers,Cl

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休閑

Nucleic Acid-Carcinogen Adducts in Human Dosimetryative contributions of various chemicals to the total burden of carcinogens, but these are very uncertain due to the difficulty of quantitatively assessing human exposure. In addition, there are likely to be substantial differences between individuals in metabolism, excretion and other parameters fo

Optometrist

Molecular Dosimetry of Genotoxic Damageeen the demonstration that genes involved in cell proliferation, whether of normally regulated cells or of cancer cells, belong to largely the same group. Many so-called proto-oncogenes have been identified and much has become known about various mechanisms leading to their conversion into active on

Lime石灰

Protein-Carcinogen Adducts in Human Dosimetryet al 1987 and references therein; Neumann 1988). To date all quantitative determinations have been carried out using hemoglobin adducts, for reasons of ready availability and stability over the long lifetime of this protein (120 days). The sensitivity required to determine these adducts in humans h

extemporaneous

Individual Exposure Monitoring from Plasma or Urinary Metabolite Determinationt of internal chemical exposure (or internal dose), both for electrophilic and non-electrophilic agents (Lauwerijs, 1983; Schulte, 1987). Internal chemical exposure is defined as the amount of a chemical which is absorbed into the body or which is already stored in the organism (body burden) (Lauwer

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下邊深陷

A Sensitive Method for the Determination of Urinary Mercapturic Acids for use in Biological Monitoriounts of physiological substrates, on the other hand, most agents excreted in this way are electrophilic compounds which often possess cancerogenic and/or mutagenic activities. Estimation of excreted mercapturic acid might reflect the extent of exposure towards such xenobiotics. In this respect, uri