Titlebook: Biochemistry of Signal Transduction in Myocardium; Jos M. J. Lamers,Pieter D. Verdouw Book 1996 Kluwer Academic Publishers 1996 Angiotensi

新鮮

Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating cnductances were studied in pairs of neonatal rat cardiomyocytes. Under dual whole-cell voltage-clamp, PKC activation by 100 nM TPA increased g. by 16 ± 2% (mean ± S.E.M, n=9), 1.5 mM of the PKG activator 8-bromo-cGMP (8Br-cGMP) decreased g. by 26 ± 2% (n=4), whereas 1.5 mM of the PKA activator 8Br-c

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可憎

Sympathetic control of cardiac myosin heavy chain gene expressionnervous system for cardiac myosin heavy chain (MHC) expression. We have used cultured fetal rat heart myocytes to investigate the role of cAMP on the α- and β-MHC gene expression. In low density cultures, addition of 1 mM 8 Br cAMP resulted in up regulation of α-MHC and down regulation of β-MHC mRNA

Gudgeon

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Kourou and the Struggle for a French Americalar smooth muscle cells and cardiac fibroblasts). New data is also presented on the presence and activity of MAPK in two additional cardiac celltypes namely atrial myocytes and vascular endothelial cells from the coronary microcirculation.

倫理學(xué)

Phosphoinositide-generated messengers in cardiac signal transductione summarize the multitude of receptor (sub)types, G-protein-subunit- and phospholipase C-isozymes that are present in the heart. Furthermore, generation of second messengers and cellular responses are described together with the (patho)physiological implications for the heart of phosphoinositide cycle activation and second messenger accumulation.