Titlebook: Biochemistry and Molecular Genetics of Cancer Metastasis; Proceedings of the S Karoly Lapis,Lance A. Liotta,Alan S. Rabson Conference proce

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l factors and gene products derived both from the host and the tumor cell may be required for the metastasizing tumor cell to invade, survive host defenses, travel in the circulation, arrest and adhere in the target organ, invade out, and grow as a metastatic colony. Some of these factors have recently been i978-1-4612-9416-0978-1-4613-2299-3

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Introduction and Overview of Book to respond to these growth inhibitory signals. These origins should be reflected in the biologic characteristics of some tumors, and an understanding of the events regulating normal cellular differentiation should provide insight into the altered growth characteristics of these malignant tumors.

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A Role for Differentiation Arrest in the Development of Neural Crest Tumors to respond to these growth inhibitory signals. These origins should be reflected in the biologic characteristics of some tumors, and an understanding of the events regulating normal cellular differentiation should provide insight into the altered growth characteristics of these malignant tumors.

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Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteinsrs must be conservative, i.e. expressed not only in well differentiated tumors but also in poorly differentiated tumors and in metastases. These criteria are fulfilled by certain components of the cytoskeleton, notably the proteins forming the intermediate-sized filaments (IFs) and the desmosomal plaque proteins.

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