Titlebook: Bioactive Lipid Mediators; Current Reviews and Takehiko Yokomizo,Makoto Murakami Book 2015 The Editor(s) (if applicable) and The Author(s)

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Omega-3 Fatty Acid Metabolism and Regulation of Inflammationcid (EPA) and docosahexaenoic acid (DHA), can suppress inflammation and play a beneficial role in a variety of inflammation-related human diseases, such as inflammatory bowel disease, rheumatoid arthritis, asthma, cancer, and cardiovascular diseases. Omega-3 PUFAs serve as substrates for the product

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Membrane Lipid Transporters in ,se translocates lipids from the exocytoplasmic to the cytoplasmic leaflet of cellular membranes, floppase mediates the translocation of lipids in the opposite direction, and scramblase facilitates bidirectional translocation of lipids. These specialized lipid transport machineries are now demonstrat

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Lipid Mediator LPA-Induced Demyelination and Self-Amplification of LPA Biosynthesis in Chronic Pain This type contrasts to the cases with acute pain, nociceptive or inflammatory pain, which vanishes without delay after the cessation of stimulation or inhibition of the original inflammation. Lysophosphatidic acid (LPA) was identified to be a key initiator of neuropathic pain, one of the representa

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Omega-3 Fatty Acid Metabolism and Regulation of Inflammationion of potent bioactive anti-inflammatory lipid mediators such as resolvins. Herein we review recent advances in understanding the formation and action of these mediators, especially focusing on the LC-ESI-MS/MS-based lipidomics approach and on recently identified bioactive compounds with potent anti-inflammatory properties.

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