Titlebook: Basic and Clinical Applications of Flow Cytometry; Proceeding of the 24 Frederick A. Valeriote,Alexander Nakeff,Manuel Val Conference proce

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Cytometry 2000: Laser Probing the Future,red on how best to utilize these data to alter the course of effective medical treatment in both a prospective and interactive fashion. There are several important but difficult issues that need to be addressed in future applications.

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DNA Topoisomerase II Poisons and the Cell Cycle, functions and operates by forming temporary gates in double stranded DNA (Fig. 1) through which an intact helix can pass. Several classes of antitumor drugs are now recognized as topoisomerase poisons because of their ability to trap the enzyme gates on DNA in the form of stabilized cleavable complexes (Fig. 1).

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978-1-4612-8534-2Kluwer Academic Publishers 1996

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Megakaryocytopoiesis 2000,the homeokinetic release of platelets into the peripheral blood. Circulating platelets are crucial to the maintenance of homeostasis and vascular integrity and play a role in tumor cell metastasis. Platelets are derived as anuclear fragments of cytoplasm from megakaryocytes resident mainly in bone marrow.

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The Lithic Assemblage of Level Jse despite conventional therapy (1–4). SJL lymphomas provide a model for development of a new treatment for this disease by revealing the existence of a novel target for therapy, nonmalignant lymphocytes upon which the tumor cells are dependent for growth (5).

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