Titlebook: Application of Nanocarriers in Brain Delivery of Therapeutics; Amit Alexander Book 2024 The Editor(s) (if applicable) and The Author(s), u

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S. Pujithaa,M. Rajamiriyam,M. K. Kalaivaniobe. As per statistics, approximately 1 in 60 Americans suffer from Alzheimer’s, and at least half a million Americans suffer from Parkinson’s. The high selectivity nature of the blood–brain barrier (BBB) prohibits the entry of all large molecules and nearly all small molecules into the brain. A phy

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T. S. Kumar,A. Josephine,G. Dharanis, memory, mood, and emotional behavior of affected people and are the second leading sources of deaths across the globe. The current treatments with the conventional delivery systems alleviate the symptoms of these disorders and fail to achieve sufficient drug concentration in the brain which ultim

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Bahar Aslanbay Guler,Esra Imamoglucell line models for brain research. These models encompass a wide array of neuronal and glial cell lines, primary cultures, and sophisticated systems that closely mimic the brain’s intricate microenvironments. They have become invaluable tools for investigating various facets of brain biology and p

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Anticoagulation For Haemodialysis,he nanocarriers derived from metals, polymers, and other materials have shown their therapeutic efficacy against several neurological disorders during in vitro and preclinical studies. However, these nanocarriers, especially metal and silica NPs, have shown their toxicity against neuronal cell lines

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Book 2024s complex brain disorders, the currently available therapies, and their limitations. The book discusses the potential applications of polymeric nanoparticles, lipid nanocarriers, liposomes, inorganic nanoparticles, dendrimers, and stimuli-responsive polymers for targeted brain drug delivery. Further

Debate

Safety, Stability Concerns, and Regulatory Aspects of Nanocarriers for Brain Delivery, via the generation of reactive oxygen species, astrogliosis, and downregulation of glutathione. The discrepancies in the result may be due to their size, surface chemistry, and shape. The interaction between nanocarriers and living systems is not clear. These factors limit the safety and regulation of nanocarriers.